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Even though the chance of dependancy in any specific is unfamiliar, it may occur in individuals properly prescribed oxycodone HCl. Addiction can take place at encouraged dosages and In the event the drug is misused or abused.Cytochrome P450 3A4 Conversation. The concomitant use of Oxycodone/acetaminophen with all cytochrome P450 3A4 inhibitors may